Inside Knowledge

We use our Ranger technology to monitor relative changes in the bioreactor culture medium in real time.

Dynamic Feeding Control (DFC)

We use our Ranger technology to determine the needs of the culture based on the metabolic activity.

Rapid Optimisation

We then allow our Ranger technology to modify your standard process, in real time, over a course of runs to determine the optimum conditions for your cell line and product.


Dynamic Feeding Control at work

Changing metabolic activity directly controls feeding rate and peak metabolic activity per feed cycle determines the effect of changes to culture environment

The image shows a simplified plot demonstrating the generation of a DFC profile using the Ranger technology. The process is:

1) Peak metabolic activity detected

2) Drop in Metabolic activity initiates feed addition

The Ranger™ Benefits


Reduce the process optimisation time required to achieve a stable and efficient process

Enhance the process by feeding specific nutrients during the different stages of the bioreactor run e.g. growth and expansion, production and secretion.

Once the process is optimised, Ranger data can also be used to identify a decline in the metabolic activity of the culture and a possible indication of a decline in cell viability.

Ranger can be used as part of a ‘dynamic process platform’ during scale-up and manufacturing.

Case studies